Investors will help save millions of patients from radiotherapy damage

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Dear investor – or potential investor

If you have invested in TRUEinvivo® already (and over 20 of you have) then, as ever, we thank you for your confidence and support for the company and the team. You already know that we send out an investor update briefing every 2-3 months and that we organise investor get-togethers once a year. You also know that we welcome questions and interest from our investors at any time.

If you are a potential investor then thank you too for your interest in TRUEinvivo®.

You will have read about the company’s technical progress (not least on these web pages) but there is much more we can tell you about the market, our IP, the business plan and the hospitals and radiotherapy centres (in the UK and overseas) that have approached us to be part of our research and development programme.

We raised our first seed round early in 2018 and launched our second round for Q1 2019. Just to be clear, this page is not a formal invitation to invest in the company. It is for general information only.

If you would like more information about TRUEinvivo please contact our CFO Chris Budleigh (chris.budleigh@trueinvivo.co.uk) or our CEO Nigel Biggs (nigel.biggs@trueinvivo.co.uk).

We have a real team ethos at TRUEinvivo® and we strive to make our investors part of that team – just as much or as little as you want to be! We look forward to talking to or meeting you.

Current Problems with Radiotherapy

  • Radiation inaccuracy causes damage to patient

  • Damage is not revealed for weeks

  • 10-25% of patients affected

  • Costs of treating damage from radiation inaccuracy

The Technology

DoseMapper is a unique high performance thermoluminescent detector (TLD) array consisting of 100+ small (1mm) micro silica glass beads packed on a flexible thread for use in a standard catheter which can be easily inserted into the patient’s most relevant natural orifice next to the tumour. The beads absorb the same radiation energy as the tumour and can be read immediately after the radiation session.

Once the bead array is removed from the patient, the radiation dose levels and pattern will be measured by our fully automated high-performance TLD reader. The results will be ready, typically, after 15 minutes, and are a unique “radiation ruler” or profile of radiation measurements along or across the tumour area and beyond. The clinician is then able to compare the actual results with their planned doses and, if necessary, can decide to make adjustments for the next session.

The glass beads are chemically inert and ideal for safe and easy disposal or recycling.

10-25% of patients are currently affected by damage from radiotherapy.

TRUEinvivo DoseMapper™ gives clinicians confidence that their patient treatment plan is accurate by measuring the location and dose of received radiation.

Beads placed in/next to tumour

DoseMapper glass beads on a thread in a catheter are placed in a patient’s natural orifice next to the tumour.

Radiotherapy treatment

The required radiation is calculated and carefully aimed at the patient’s tumour. However the clinician is unable to see what actually happens in the body and what else may be hit.

Adjustments made

The DoseMapper™ glass beads absorb the same received energy and show how much radiation the patient experienced at and around the tumour. The clinician can then decide if any adjustments are needed to the treatment plan.

Possible annual savings of £45M in the UK

Not only are DoseMapper™ micro silica bead array detectors inexpensive and recyclable, there is the potential for huge savings associated with less damage to patients and a much improved quality of life.

Key Benefits

  • Using DoseMapperenables clinicians to reduce patient damage and the related extra medical costs.
  • It can cost about £10,000 per patient to treat damage from inaccurate radiotherapy.
  • Clinicians could save 7,000 patients from damage and £45m in costs annually in the UK alone.
  • DoseMapper™ beads are inexpensive, recyclable, and work in difficult environments.
  • Reader outputs data in 15 minutes, allowing clinicians and operators to use the measurements quickly if required.
  • Other potential applications are in fields such as nuclear, animal health, aerospace, defence and more.
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TRUEinvivo helps to improve cancer care worldwide!

To find out more about how TRUEinvivo technology is being implemented in hospitals around the country, please get in touch.
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